GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs11190604 | 1 | rs1054399 | chr10:102312565 | SEC31B | chr10:102246403-102289636:- | -0.27 | -10.01 | 1.37E-22 | Palmitoleic acid (16:1n-7) plasma levels |
| BRCA | cis | rs1056667 | 1 | rs1056667 | chr6:26510564 | BTN2A3 | chr6:26422317-26431927:+ | 0.16 | 5.42 | 7.18E-8 | Educational attainment |
| BRCA | cis | rs1056667 | 1 | rs1056667 | chr6:26510564 | ZNF322A | chr6:26634612-26659963:- | -0.1 | -3.46 | 0.000559 | Educational attainment |
| BRCA | cis | rs3771570 | 1 | rs1056801 | chr2:242292307 | ANO7 | chr2:242127924-242164791:+ | 0.21 | 3.37 | 0.000768 | Prostate cancer |
| BRCA | cis | rs7679 | 1 | rs1057208 | chr20:44563007 | SLC12A5 | chr20:44650329-44688789:+ | 0.21 | 3.82 | 0.00014 | HDL cholesterol;Triglycerides;Gut microbiota (functional units) |
| BRCA | cis | rs9311474 | 1 | rs1060330 | chr3:52288945 | SPCS1 | chr3:52739857-52742195:+ | 0.12 | 3.79 | 0.00016 | Electroencephalogram traits |
| BRCA | cis | rs1061377 | 1 | rs1061377 | chr4:39124750 | KLHL5 | chr4:39046659-39123828:+ | -0.14 | -4.45 | 9.41E-6 | Uric acid levels |
| BRCA | cis | rs6087771 | 1 | rs1062794 | chr20:30381758 | COX4I2 | chr20:30225691-30232800:+ | 0.19 | 7.1 | 2.31E-12 | Subcortical brain region volumes |
| BRCA | cis | rs6087771 | 1 | rs1062794 | chr20:30381758 | MYLK2 | chr20:30407178-30422500:+ | 0.31 | 8.17 | 8.46E-16 | Subcortical brain region volumes |
| BRCA | cis | rs911119 | 1 | rs1064039 | chr20:23618427 | CST1 | chr20:23728191-23731574:- | 0.23 | 5 | 6.65E-7 | Chronic kidney disease |
| BRCA | cis | rs9783347 | 1 | rs10734259 | chr11:18314865 | GTF2H1 | chr11:18343816-18388590:+ | 0.29 | 7.52 | 1.15E-13 | Pancreatic cancer |
| BRCA | cis | rs10160456 | 1 | rs10734389 | chr11:27331452 | LGR4 | chr11:27387510-27494334:- | 0.14 | 4.15 | 3.57E-5 | Bone mineral density (paediatric, skull) |
| BRCA | cis | rs10160456 | 1 | rs10734390 | chr11:27332214 | LGR4 | chr11:27387510-27494334:- | 0.15 | 4.22 | 2.62E-5 | Bone mineral density (paediatric, skull) |
| BRCA | cis | rs6487679 | 1 | rs10734765 | chr12:9369385 | LOC642846 | chr12:9436253-9466684:+ | 0.14 | 4.84 | 1.52E-6 | Non-alcoholic fatty liver disease histology (AST) |
| BRCA | cis | rs4660306 | 1 | rs10736426 | chr1:45984353 | CCDC163P | chr1:45960581-45965646:- | 0.71 | 23.08 | 5.87E-96 | Homocysteine levels |